Calsyntenin是什么
WebJul 14, 2015 · Calsyntenin-2 has an evolutionarily conserved role in cognition. In a human genome-wide screen, the CLSTN2 locus was associated with verbal episodic memory, and expression of human calsyntenin-2 ... WebAug 8, 2012 · Calsyntenin-1 is cleaved by ADAM10 in early endosomes. Immunoisolated organelles were solubilized immediately or after incubation for 30 minutes at 37°C …
Calsyntenin是什么
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WebMay 31, 2024 · Here, we show that acute CRISPR-mediated deletion of calsyntenin-3 in cerebellar Purkinje cells in vivo causes a large decrease in inhibitory synapses, but a surprisingly robust increase in excitatory parallel-fiber synapses. No changes in the dendritic architecture of Purkinje cells or in climbing-fiber synapses were detected. Web学习和记忆相关基因:Calsyntenins家族. Calsyntenins (Cstn)是一个独特的将胞外蛋白水解活性与胞内Ca2+信号转导相连在一起的家族,属于钙结合蛋白,与钙离子结合,参与信号转导 …
WebJul 1, 2006 · Calsyntenin-1 is a dynamic modulator of postsynaptic calcium by extracellular proteolysis. Calsyntenin-1 may modulate Ca2+ transients locally either beneath the postsynaptic membrane or around intracellular Ca2+ stores, such as LTP and LTD. Recent studies showed that impairment of the coordinated metabolic regulation of APP and …
WebMay 2, 2024 · 曾等在《自然》杂志发表论文，发现calsyntenin 3β (CLSTN3β)在神经纤维支配褐色脂肪中发挥关键作用，能通过调节生长因子S100b蛋白的分泌影响褐色脂肪产热 … Calsyntenins (Csts, CLSTN) are type I transmembrane proteins that belong to the cadherin superfamily. Their name comes from their ability to bind calcium. In birds and mammals, they consist of three family members (Cst1, 2 and 3), in nematodes one ortholog (CASY-1, originally CDH11) is known. Cst1 (CLSTN1) was first shown to be predominantly expressed in postsynaptic membranes of ex…
WebSep 22, 2024 · This gene is a member of the calsyntenin family, a subset of the cadherin superfamily. The encoded transmembrane protein, also known as alcadein-alpha, is thought to bind to kinesin-1 motors to mediate the axonal anterograde transport of certain types of vesicle. Amyloid precursor protein (APP) is trafficked via these vesicles and so this …
WebApr 14, 2024 · This study investigated the role of calsyntenin-3, an atypical cadherin, in controlling synaptic inputs to cerebellar Purkinje cells. It provides compelling evidence that elimination of calsyntenin-3 from cells in the cerebellar cortex alters the E/I balance for Purkinje cells, although Purkinje cell-specific manipulations were used in only some of … exertis supply chainWebOct 2, 2013 · To better assess synaptogenic function of calsyntenin-3, we added a Myc tag at its mature N terminus and a CFP tag at its C terminus. These tags did not alter the activity of calsyntenin-3 to induce clustering of synapsin in the coculture assay (Figures S1 C and S1D).Myc-calsyntenin-3-CFP also induced clustering of the synaptic vesicle protein … bt fttp third party routerWebApr 14, 2024 · Sparse selective deletion of calsyntenin-3 only in Purkinje cells recapitulated the synaptic phenotype, indicating that calsyntenin-3 acts by a cell-autonomous … exertis terms and conditions of saleWebAug 8, 2012 · Calsyntenin-1 is cleaved by ADAM10 in early endosomes. Immunoisolated organelles were solubilized immediately or after incubation for 30 minutes at 37°C without or with inhibitors. Full-length calsyntenin-1 and APP, as well as their cleavage products, were assessed by Western blotting. The endosomal markers Rab11, syntaxin13, and VAMP2 … exertis supply chain services limitedWebMay 1, 2024 · The newly identified calsyntenin 3β protein has a role in the innervation of thermogenic fat through a mechanism of … exertis telecomWebMay 31, 2024 · Here, we show that acute CRISPR-mediated deletion of calsyntenin-3 in cerebellar Purkinje cells in vivo causes a large decrease in inhibitory synapses, but a … bt fttp reviewsWebCalsyntenin-1: Products. Calsyntenin-1 (CST-1; also Alcadein-alpha) is a 140 - 150 kDa member of the Alcadein family of molecules. It is expressed in the ER/Golgi and on the … bt full fibre 100 with bt halo 3