Glut9 isoform2
WebSep 18, 2024 · RT-PCR detected GLUT9 mainly in liver, kidney, and placenta, with weaker expression in lung, leukocytes, and brain. GLUT9-delta-N was detected only in kidney and placenta. Western blot analysis revealed multiple GLUT9 protein bands between 48 and 55 kD in plasma membrane and high density microsomal fractions of human kidney. WebApr 13, 2024 · View Atlanta obituaries on Legacy, the most timely and comprehensive collection of local obituaries for Atlanta, Georgia, updated regularly throughout the day …
Glut9 isoform2
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WebMar 28, 2024 · Stuart CA, Yin D, Howell ME, Dykes RJ, Laffan JJ, Ferrando AA. Hexose transporter mRNAs for GLUT4, GLUT5, and GLUT12 predominate in human muscle. Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E1067-73. doi: 10.1152/ajpendo.00250.2006. Epub 2006 Jun 27. WebBased on these results, one can conclude that the increased concen-tration of glucose in the lumen by SGLT2 inhibition stimulates uric acid excretion mediated by GLUT9 isoform 2 or any other transporter(s) in the proxi-mal tubule and inhibits uric acid reabsorption mediated by GLUT9 isoform2 in the collecting duct (Figure 8).
WebApr 23, 2024 · This work aimed to investigate the effect of fucoidan (FPS) on urate transporters induced by uric acid (UA). The results showed that UA stimulated the expression of glucose transporter 9 (GLUT9) and urate transporter 1 (URAT1) in HK-2 cells, and FPS could reverse the effect. Moreover, UA could activate NF-κB, JNK and PI3K/Akt … WebMar 25, 2024 · In GLUT9-expressing HEK293T cells, CDER167 concentration-dependently inhibited GLUT9 with an IC 50 value of 91.55 ± 15.28 μM, whereas RDEA3170 at 100 μM had no effect on GLUT9.
WebGlucose transporter 9 (GLUT9), which transports urate in an electrogenic and voltage-dependent manner, plays an important role in the maintenance of normal blood uric acid/urate levels. In the present study, we established a cell model based on the single-electrode patch-clamp technique for characte …
Web(B,C) The stimulatory effect of insulin (1.0 µM) on [ 14 C]-urate uptake mediated by GLUT9 isoforms, OAT10, NPT1, mouse OAT3 and OAT1 in Xenopus oocytes was measured in the absence and presence ... fertitily bozemanWebJan 1, 2024 · Glucose transporter (Glut) 9 plays an important role in maintaining the homeostasis of uric acid in the body. Although the physiologic functions of Glut9 have been well established, the regulation of Glut9 expression is less well understood. In this study, we showed that the mRNA and protein expression of Glut9 in mouse liver and kidney are … dell monitor split screen softwareWebGLUT9 was found to be expressed in the ileal and colonic apical membranes, but the level of expression of this protein in the colon was decreased by the HC diet. These data … dell monitor sound bar installationWebJun 18, 2024 · SLC2A9 or Glut9 is a voltage sensitive urate transporter, mainly expressed in the kidneys, the liver, and the intestine. Human Glut9 loss-of-function mutations were identified in familial hypouricemia, and … dell monitor speakers no soundWebCurrent Weather. 5:11 AM. 47° F. RealFeel® 48°. Air Quality Excellent. Wind NE 2 mph. Wind Gusts 5 mph. Clear More Details. dell monitor speaker bar power adapterWebDownload scientific diagram The N-terminal domain of human GLUT9 isoforms play a significant role in functional activation of by insulin. (A,B) The [ 14 C]-urate uptake … dell monitor software windows 10WebOct 22, 2024 · Hyperuricemia plays a critical causative role in gout. In contrast, hyperuricemia has a protective effect in neurodegenerative disorders, including Alzheimer’s Disease. Genetic variation in the … dell monitors sound not working